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Hyperpigmentation Due to Pyrimethamine Use
Author(s) -
Ozturk Recep,
Engin Aynur,
Ozaras Resat,
Mert Ali,
Tabak Fehmi,
Aktuĝlu Yildirim
Publication year - 2002
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2002.tb00303.x
Subject(s) - hyperpigmentation , megaloblastic anemia , pyrimethamine , medicine , leukopenia , vomiting , dermatology , rash , diarrhea , etiology , malaria , anemia , pediatrics , immunology , chloroquine , chemotherapy
Pyrimethamine is used for the treatment of toxoplasmosis and the prophylaxis of malaria. Among the well‐documented side effects are megaloblastic anemia, leukopenia, thrombopenia, rash, vomiting, and diarrhea. Hyperpigmentation is a very rare side effect. In some patients, associated HIV infection makes it difficult to distinguish the reasons for the etiology. We herein describe an HIV‐negative patient who developed hyperpigmentation after pyrimethamine use.