Electron Microscopic Study of Langerhans Cell Histiocytosis

Among the several forms of Langerhans cell histiocytosis (LCH), Letterer‐Siwe disease is the most acute disseminated multisystemic variant. The course of Letterer‐Siwe disease is usually rapid and fatal. We report here a cases of Letterer‐Siwe disease which showed a good response to chemotherapy. We also describe the unusual ultrastructural findings in the histiocyte‐like cells in this case.