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Targeting plasmid‐encoded proteins to the antigen presentation pathways
Author(s) -
Leifert Jens A.,
RodriguezCarreno Maria P.,
Rodriguez Fernando,
Lindsay Whitton J.
Publication year - 2004
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.0105-2896.2004.0135.x
Subject(s) - biology , computational biology , antigen presentation , presentation (obstetrics) , immune system , acquired immune system , immunity , antigen , plasmid , immunology , genetics , dna , medicine , t cell , radiology
Summary: The antigen presentation pathways constitute a fulcrum on which adaptive immunity is balanced, and their manipulation should allow us to induce designer immune responses. The ease and rapidity with which DNA vaccines can be constructed and altered make them ideal candidates with which to test the various targeting strategies that have been conceived to date. These approaches and the mechanisms that may (or may not) underlie their success are reviewed in this article.