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CD11c participates in triggering acute graft‐versus‐host disease during bone marrow transplantation
Author(s) -
Wang Qianqian,
Su Xiuhua,
He Yi,
Wang Mei,
Yang Donglin,
Zhang Rongli,
Wei Jialin,
Ma Qiaoling,
Zhai Weihua,
Pang Aiming,
Huang Yong,
Feng Sizhou,
Ballantyne Christie M.,
Wu Huaizhu,
Pei Xiaolei,
Feng Xiaoming,
Han Mingzhe,
Jiang Erlie
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13350
Subject(s) - cd11c , immunology , immune system , bone marrow , cd8 , biology , transplantation , t cell , peripheral blood mononuclear cell , cancer research , medicine , phenotype , biochemistry , gene , in vitro
CD11c is a canonical dendritic cell (DC) marker with poorly defined functions in the immune system. Here, we found that blocking CD11c on human peripheral blood mononuclear cell‐derived DCs (MoDCs) inhibited the proliferation of CD4 + T cells and the differentiation into IFN‐γ‐producing T helper 1 (Th1) cells, which were critical in acute graft‐versus‐host disease (aGVHD) pathogenesis. Using allogeneic bone marrow transplantation (allo‐BMT) murine models, we consistently found that CD11c‐deficient recipient mice had alleviated aGVHD symptoms for the decreased IFN‐γ‐expressing CD4 + Th1 cells and CD8 + T cells. Transcriptional analysis showed that CD11c participated in several immune regulation functions including maintaining antigen presentation of APCs. CD11c‐deficient bone marrow‐derived DCs (BMDCs) impaired the antigen presentation function in coculture assay. Mechanistically, CD11c interacted with MHCII and Hsp90 and participated in the phosphorylation of Akt and Erk1/2 in DCs after multiple inflammatory stimulations. Therefore, CD11c played crucial roles in triggering aGVHD and might serve as a potential target for the prevention and treatment of aGVHD.