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The NLRP6 inflammasome
Author(s) -
Zheng Danping,
Kern Lara,
Elinav Eran
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13293
Subject(s) - inflammasome , pyrin domain , aim2 , innate immune system , biology , microbiology and biotechnology , pattern recognition receptor , caspase 1 , nlrc4 , immunology , immune system , inflammation
In this review, we summarize recent understandings on the assembly, activation and regulation patterns of the NLRP6 inflammasome, as well as its diverse impacts on tissue homeostasis and disease in multiple organs.