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Summary   Excessive inflammatory immune responses during infections with  Plasmodium  parasites are responsible for severe complications such as cerebral malaria (CM) that can be studied experimentally in mice. Dendritic cells (DCs) activate cytotoxic CD8 +  T‐cells and initiate immune responses against the parasites.  Batf3  −/−  mice lack a DC subset, which efficiently induces strong CD8 T‐cell responses by cross‐presentation of exogenous antigens. Here we show that  Batf3  −/−  mice infected with  Plasmodium berghei ANKA  (PbA) were protected from experimental CM (ECM), characterized by a stable blood−brain barrier (BBB) and significantly less infiltrated peripheral immune cells in the brain. Importantly, the absence of ECM in  Batf3  −/−  mice correlated with attenuated responses of cytotoxic T‐cells, as their parasite‐specific lytic activity as well as the production of interferon gamma and granzyme B were significantly decreased. Remarkably, spleens of ECM‐protected  Batf3  −/−  mice had elevated levels of regulatory immune cells and interleukin 10. Thus, protection from ECM in PbA‐infected  Batf3  −/−  mice was associated with the absence of strong CD8 +  T‐cell activity and induction of immunoregulatory mediators and cells.

Protection of Batf3 ‐deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T‐cell responses and immune regulation