English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Summary  Community‐acquired pneumonia ( CAP ) is the leading infectious disease requiring hospitalization in the western world. Genetic variability affecting the host response to infection may play a role in susceptibility and outcome in patients with  CAP . Mannose‐binding lectin ( MBL ) and  l ‐ficolin ( l ‐ FCN ) are two important activators of the complement system and they can enhance phagocytosis by opsonization. In a prospective cohort of 505 Dutch patients with  CAP  and 227 control participants we studied whether polymorphisms in the  MBL  (  MBL 2 ) and  FCN  (  FCN 2 ) genes influenced susceptibility and outcome. No difference in frequency of these genotypes was found between patients with  CAP  in general and controls. However, the +6424G>T single nucleotide polymorphism ( SNP ) in   FCN 2  was more common in patients with a  Coxiella burnetii  pneumonia ( P  =   0·014). Moreover, the haplotypes coding for the highest  MBL  serum levels ( YA / YA  and  YA / XA ) predisposed to atypical pneumonia ( C. burnetii ,  Legionella  or  Chlamydia  species or  Mycoplasma pneumoniae ) compared with controls ( P  = 0·016). Furthermore, patients with these haplotypes were more often bacteraemic ( P  = 0·019). It can therefore be concluded that   MBL 2  and   FCN 2  polymorphisms are not major risk factors for  CAP  in general, but that the +6424G>T  SNP  in the   FCN 2  gene predisposes to  C. burnetii  pneumonia. In addition, patients with genotypes corresponding with high serum  MBL  levels are at risk for atypical pneumonia, possibly caused by enhanced phagocytosis, thereby promoting cell entry of these intracellular bacteria.

Mannose‐binding lectin and l ‐ficolin polymorphisms in patients with community‐acquired pneumonia caused by intracellular pathogens