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Predicting success of a therapy in acute respiratory failure is clinically important. The FOx index (high‐flow rate × FiO 2 )/SpO 2  was retrospectively applied to 70 patients who required high‐flow nasal prongs for hypoxaemic and hypercapnic respiratory failure. The FOx index could predict between success and failure of high‐flow nasal prongs at 6 hours, using non‐invasive markers. This adds to the clinician's toolbox in managing respiratory failure and represents important proof of concept for a prospective study.

A novel non‐invasive index of oxygenation and prediction of outcomes for patients on high‐flow nasal cannula: a pilot study