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Many endoparasitoids adopt several parasitic factors, such as venom, polydnavirus and teratocytes, to suppress the immune response of their associated hosts including melanization for successful parasitism. A teratocyte‐specific expressed serpin gene, designated as  CvT‐serpin6 , was identified from the parasitoid  Cotesia vestalis . The immunoblot result suggested that CvT‐serpin6 was secreted into extracellular space. qPCR results showed that  CvT‐serpin6  was mainly transcribed at later stages of parasitism, and the transcriptional abundance of  CvT‐serpin6  in teratocytes was significantly increased in response to the challenge of bacteria. Inhibitory assay indicated that recombinant CvT‐serpin6 (rCvT‐serpin6) could inhibit the activation of  Plutella xylostella  prophenoloxidase and ultimately resulted in the inhibition of melanization in  P. xylostella  haemolymph. Furthermore, we confirmed that rCvT‐serpin6 could form SDS‐stable complexes with activated  Px PAP1 and  Px PAP3 in a dose‐dependent manner. Altogether, our results further shed insight into the molecular mechanisms that teratocytes involved in controlling host immune response.

insect molecular biology

A teratocyte‐specific serpin from the endoparasitoid wasp  Cotesia vestalis  inhibits the prophenoloxidase‐activating system of its host  Plutella xylostella