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Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report
Author(s) -
Seitz Susanne,
Lange Vinzenz,
Norman Paul J.,
Sauter Jürgen,
Schmidt Alexander H.
Publication year - 2021
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12553
Subject(s) - haplotype , german , human leukocyte antigen , expectation–maximization algorithm , sample (material) , genetics , maximum likelihood , biology , statistics , mathematics , allele , physics , gene , geography , archaeology , antigen , thermodynamics
We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation‐maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.