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Immunogenetics in stem cell donor registry work: The DKMS example (Part 2)
Author(s) -
Schmidt Alexander H.,
Sauter Jürgen,
Baier Daniel M.,
Daiss Jessica,
Keller Andreas,
Klussmeier Anja,
Mengling Thilo,
Rall Gabi,
Riethmüller Tobias,
Schöfl Gerhard,
Solloch Ute V.,
Torosian Tigran,
Means David,
Kelly Helen,
Jagannathan Latha,
Paul Patrick,
Giani Anette S.,
Hildebrand Sabine,
Schumacher Stephan,
Markert Jan,
Füssel Monika,
Hofmann Jan A.,
Schäfer Thomas,
Pingel Julia,
Lange Vinzenz,
Schetelig Johannes
Publication year - 2020
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12479
Subject(s) - biobank , donation , human leukocyte antigen , context (archaeology) , serostatus , medicine , identification (biology) , population , genetics , family medicine , biology , immunology , political science , law , paleontology , botany , environmental health , human immunodeficiency virus (hiv) , antigen , viral load
Abstract DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two‐part review article, we deal with these aspects of donor registry work by using the example of DKMS. In the second part of the review, we focus on donor typing of non‐HLA genes, the impact of donor age, gender and CMV serostatus on donation probabilities, the identification of novel HLA, KIR and MIC alleles by high‐throughput donor typing, the activities of the Collaborative Biobank and pharmacogenetics in the donor registry context.