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Immunogenetics in stem cell donor registry work: The DKMS example (Part 1)
Author(s) -
Schmidt Alexander H.,
Sauter Jürgen,
Baier Daniel M.,
Daiss Jessica,
Keller Andreas,
Klussmeier Anja,
Mengling Thilo,
Rall Gabi,
Riethmüller Tobias,
Schöfl Gerhard,
Solloch Ute V.,
Torosian Tigran,
Means David,
Kelly Helen,
Jagannathan Latha,
Paul Patrick,
Giani Anette S.,
Hildebrand Sabine,
Schumacher Stephan,
Markert Jan,
Füssel Monika,
Hofmann Jan A.,
Schäfer Thomas,
Pingel Julia,
Lange Vinzenz,
Schetelig Johannes
Publication year - 2020
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12471
Subject(s) - human leukocyte antigen , stem cell , population , immunogenetics , medicine , immunology , biology , genetics , environmental health , antigen
Abstract Currently, stem cell donor registries include more than 35 million potential donors worldwide to provide HLA‐matched stem cell products for patients in need of an unrelated donor transplant. DKMS is a leading stem cell donor registry with more than 9 million donors from Germany, Poland, the United States, the United Kingdom, India and Chile. DKMS donors have donated hematopoietic stem cells more than 80,000 times. Many aspects of donor registry work are closely related to topics from immunogenetics or population genetics. In this two‐part review article, we describe, analyse and discuss these areas of donor registry work by using the example of DKMS. Part 1 of the review gives a general overview on DKMS and includes typical donor registry activities with special focus on the HLA system: high‐throughput HLA typing of potential stem cell donors, HLA haplotype frequencies and resulting matching probabilities, and donor file optimization with regard to HLA diversity.