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HLA‐DRB1 gene polymorphisms and its associations with rheumatoid arthritis in Chinese Han women of Shaanxi province, northwest of China
Author(s) -
Wang J.,
Zhang H.,
Wang G.Q.,
Quan Y.
Publication year - 2016
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12242
Subject(s) - allele , rheumatoid arthritis , polyarthritis , medicine , han chinese , immunology , gastroenterology , allele frequency , polymorphism (computer science) , human leukocyte antigen , population , arthritis , single nucleotide polymorphism , genetics , genotype , gene , biology , antigen , environmental health
Summary Rheumatoid arthritis (RA) is a common chronic autoimmune disease characterized by symmetric polyarthritis. This study was designed to investigate the associations between HLA‐DRB1 gene polymorphisms and RA in the Chinese Han population of Shaanxi province, northwest of China. In total, we identified 31 high‐resolution HLA‐DRB1 alleles in 109 patients with RA. Compared with the controls, the AF of HLA‐DRB1* 04:05 ( P = 0.000, P c = 0.007, OR = 3.462, 95%CI: 1.749–6.852) was significantly higher in patients with RA. In addition, the patients with RA had higher allele frequency (AF) of the HLA‐DRB1* 04:03 ( P = 0.030, P c = NS, OR = 4.737, 95%CI: 1.012–22.180); DRB1* 04:06 ( P = 0.018, P c = NS, OR = 5.288, 95%CI: 1.145–24.422) and the shared epitope (SE) alleles ( P = 0.004, P c = NS, OR = 2.166, 95%CI: 1.279–3.667), respectively. Moreover, positive possibilities of RF and anti‐CCP were significant higher in SE‐positive patients compared to SR‐negative patients (OR = 4.787, 95%CI: 1.101–20.824; OR = 3.775, 95%CI: 1.106–12.876, respectively). Our results indicated that HLA‐DRB1*04:05, *04:03, *04:06 and SE alleles might be susceptibility allele for RA in Chinese Han population of Shaanxi province, northwest of China.