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IL‐17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art
Author(s) -
Bernardini Nicoletta,
Skroza Nevena,
Tolino Ersilia,
Mambrin Alessandra,
Anzalone Alessia,
Balduzzi Veronica,
Colapietra Daniela,
Marchesiello Anna,
Michelini Simone,
Proietti Ilaria,
Potenza Concetta
Publication year - 2020
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.14695
Subject(s) - hidradenitis suppurativa , medicine , vitiligo , psoriasis , alopecia areata , dermatology , atopic dermatitis , acne , immunology , disease , pathology
Recent data support the theory of the involvement of IL‐17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL‐17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL‐17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers.