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The 2015 Paediatric  E uropean Network for Treatment of  AIDS  ( PENTA ) guidelines provide practical recommendations on the management of  HIV ‐1 infection in children in  E urope and are an update to those published in 2009. Aims of treatment have progressed significantly over the last decade, moving far beyond limitation of short‐term morbidity and mortality to optimizing health status for adult life and minimizing the impact of chronic  HIV  infection on immune system development and health in general. Additionally, there is a greater need for increased awareness and minimization of long‐term drug toxicity. The main updates to the previous guidelines include: an increase in the number of indications for antiretroviral therapy ( ART ) at all ages (higher  CD4  thresholds for consideration of  ART  initiation and additional clinical indications), revised guidance on first‐ and second‐line  ART  recommendations, including more recently available drug classes, expanded guidance on management of coinfections (including tuberculosis, hepatitis  B  and hepatitis  C ) and additional emphasis on the needs of adolescents as they approach transition to adult services. There is a new section on the current  ART  ‘pipeline’ of drug development, a comprehensive summary table of currently recommended  ART  with dosing recommendations. Differences between  PENTA  and current  US  and World Health Organization guidelines are highlighted and explained.

hiv medicine

Paediatric  E uropean  N etwork for  T reatment of  AIDS  ( PENTA ) guidelines for treatment of paediatric  HIV ‐1 infection 2015: optimizing health in preparation for adult life