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Prostate cancer growth patterns beyond the Gleason score: entering a new era of comprehensive tumour grading
Author(s) -
Leenders Geert J L H,
Verhoef Esther I,
Hollemans Eva
Publication year - 2020
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.14214
Subject(s) - grading (engineering) , prostate cancer , cribriform , risk stratification , medicine , prostate , oncology , cancer , biology , carcinoma , ecology
The Gleason grading system is one of the most important factors in clinical decision‐making for prostate cancer patients, and is entirely based on the classification of tumour growth patterns. In recent years it has become clear that some individual growth patterns themselves have independent prognostic value, and could be used for better personalised risk stratification. In this review we summarise recent literature on the clinicopathological value and molecular characteristics of individual prostate cancer growth patterns, and show how these, most particularly cribriform architecture, could alter treatment decisions for prostate cancer patients.