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Aims  Tumour deposits ( TD s) are clusters of cancer cells in the soft tissue that are discontinuous from the primary tumour. In this review we are exploring their relevance for prognosis in patients with gastric cancer.    Methods and results  A literature search was performed to identify studies providing data on  TD s and prognosis in gastric cancer patients. Eight papers were included in the meta‐analysis, which was carried out in terms of risk ratios ( RR ) and hazard ratios ( HR ) with 95% confidence interval (95%  CI ). Of 7445 patients, 1551 had  TD s (20.9%).  TD s were associated with a decreased overall survival ( OS ) in univariate ( HR  = 2.82, 95%  CI  = 1.9–4.3) and multivariate analyses ( HR  = 1.65, 95%  CI  = 1.3–2.1).  TD s were also associated with known prognostic factors such as synchronous metastatic disease ( RR  = 9.5), invasion depth ( RR  = 1.8), lymph node metastasis ( RR  = 1.7), lymphatic invasion ( RR  = 1.7), vascular invasion ( RR  = 2.6) and poor differentiation ( RR  = 1.2).    Conclusions  We found a strong indication that  TD s are independent predictors of prognosis in patients with gastric cancer; hence,  TD s should be included in the staging of gastric cancers.

Tumour deposits are a significant prognostic factor in gastric cancer – a systematic review and meta‐analysis