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Invasive lobular breast cancer: the prognostic impact of histopathological grade, E ‐cadherin and molecular subtypes
Author(s) -
Engstrøm Monica J,
Opdahl Signe,
Vatten Lars J,
Haugen Olav A,
Bofin Anna M
Publication year - 2015
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12572
Subject(s) - invasive lobular carcinoma , grading (engineering) , cytokeratin , breast cancer , immunohistochemistry , progesterone receptor , medicine , epidermal growth factor receptor , pathology , invasive ductal carcinoma , human epidermal growth factor receptor 2 , oncology , cancer , estrogen receptor , biology , ecology
Aims The aim of this study was to compare breast cancer specific survival ( BCSS ) for invasive lobular carcinoma ( ILC ) and invasive ductal carcinoma ( IDC ) and, further, to evaluate critically the prognostic value of histopathological grading of ILC and examine E‐cadherin as a prognostic marker in ILC . Methods and results The study comprised 116 lobular and 611 ductal breast carcinomas occurring between 1961 and 2008. All cases had been classified previously according to histopathological type and grade, stained for oestrogen receptor ( ER ), progesterone receptor ( PR ), antigen Ki67 (Ki67), epithelial growth factor receptor ( EGFR ), cytokeratin 5 ( CK 5) and human epidermal growth factor receptor 2 ( HER 2) and classified into molecular subtypes. For the present study, immunohistochemical staining for E‐cadherin was performed. The Kaplan–Meier method and Cox proportional hazards models were used in the analyses. Grade 2 tumours comprised 85.3% of the lobular tumours and 51.9% of the ductal tumours. BCSS in ILC grade 2 was comparable to that of IDC grade 3. E‐cadherin‐negative ILC had a poorer prognosis compared to E‐cadherin positive ILC and to IDC regardless of E‐cadherin status. Conclusions The implication of histopathological grading may differ in ILC compared to IDC . E‐cadherin may be useful in prognostication in ILC and thereby influence the determination of treatment strategies for this group of women.