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DRAMing for autophagy
Author(s) -
Leytens Alexandre,
Dengjel Jörn
Publication year - 2022
Publication title -
the febs journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.16394
Subject(s) - autophagy , crosstalk , cytoprotection , microbiology and biotechnology , dram , apoptosis , biology , programmed cell death , neuroscience , genetics , computer science , engineering , computer hardware , electronic engineering
Autophagy, a catabolic lysosomal recycling pathway, is often found dysregulated in human diseases. Whereas its prime cell stress-related function is cytoprotection, autophagy has also been linked to the activation of apoptosis and cell death. One group of proteins which participates in the orchestration of autophagy and apoptosis is the family of DRAM proteins. In the current issue of The FEBS Journal, Barthet et al. uncover a compensatory crosstalk between the two newest members of the family, DRAM-4 and DRAM-5, the latter one regulating autophagic activity. Comment on https://doi.org/10.1111/febs.16365.