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Protein S‐Palmitoylation: advances and challenges in studying a therapeutically important lipid modification
Author(s) -
Main Alice,
Fuller William
Publication year - 2022
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15781
Subject(s) - palmitoylation , posttranslational modification , computational biology , function (biology) , protein function , neuroscience , biology , microbiology and biotechnology , enzyme , biochemistry , cysteine , gene
The lipid post‐translational modification S‐palmitoylation is a vast developing field, with the modification itself and the enzymes that catalyse the reversible reaction implicated in a number of diseases. In this review, we discuss the past and recent advances in the experimental tools used in this field, including pharmacological tools, animal models and techniques to understand how palmitoylation controls protein localisation and function. Additionally, we discuss the obstacles to overcome in order to advance the field, particularly to the point at which modulating palmitoylation may be achieved as a therapeutic strategy.