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Second sialic acid‐binding site of influenza A virus neuraminidase: binding receptors for efficient release
Author(s) -
Du Wenjuan,
de Vries Erik,
van Kuppeveld Frank J. M.,
Matrosovich Mikhail,
de Haan Cornelis A. M.
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15668
Subject(s) - neuraminidase , biology , sialic acid , hemagglutinin (influenza) , virus , influenza a virus , binding site , receptor , viral envelope , tropism , sialidase , viral replication , virology , host (biology) , glycoprotein , microbiology and biotechnology , biochemistry , genetics
Influenza A viruses contain sialic acid (SIA) receptor‐binding hemagglutinin (HA) and receptor‐destroying neuraminidase (NA). The balance between HA and NA is adjusted to the SIA receptor repertoire of the host species. Besides a conserved catalytic site, NA carries a 2nd SIA‐binding site (2SBS). The 2SBS enhances the activity of the catalytic site and affects the HA‐NA balance. Conservation or loss of the 2SBS is associated with (changes in) host tropism.