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β‐catenin regulates FOXP2 transcriptional activity via multiple binding sites
Author(s) -
Richter Gesa,
Gui Tianshu,
Bourgeois Benjamin,
Koyani Chintan N.,
Ulz Peter,
Heitzer Ellen,
Lewinski Dirk,
Burgering Boudewijn M. T.,
Malle Ernst,
Madl Tobias
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15656
Subject(s) - foxp2 , wnt signaling pathway , transcription factor , biology , transcriptional regulation , microbiology and biotechnology , nuclear localization sequence , transcription (linguistics) , forkhead transcription factors , genetics , gene , signal transduction , cytoplasm , linguistics , philosophy
When the Wnt pathway is off duty, the transcription factor FOXP2 can up‐ and downregulate the transcription of a set of genes including Wnt‐related targets. Upon activation of the Wnt pathway, β‐catenin via direct interaction with FOXP2 can modulate its transcriptional activity in a TCF/LEF‐dependent and/or TCF/LEF‐independent manner.