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Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells
Author(s) -
Kobayashi Taeko,
Kageyama Ryoichiro
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15555
Subject(s) - proteostasis , neural stem cell , biology , microbiology and biotechnology , neurogenesis , stem cell , cell cycle , signal transduction , adult stem cell , neuroscience , cell , cellular differentiation , biochemistry , gene
Neural stem cells (NSCs) are mainly quiescent in the adult brain. Quiescent NSCs reenter the cell cycle and generate new neurons after they are activated. Recent studies suggest significant involvement of cellular proteostasis in quiescence of adult NSCs. We discuss regulation of quiescence by multiple signaling pathways and focus on the functional involvement of the lysosome, an organelle governing cellular degradation.