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R ‐hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis —A new entry to the carrier protein family Lipocalines
Author(s) -
Motojima Fumihiro,
Izumi Atsushi,
Nuylert Aem,
Zhai Zhenyu,
Dadashipour Mohammad,
Shichida Sayaka,
Yamaguchi Takuya,
Nakano Shogo,
Asano Yasuhisa
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15490
Subject(s) - cyanohydrin , chemistry , lyase , trimethylsilyl cyanide , stereochemistry , nitrile , aldehyde , cyanide , organic chemistry , enzyme , catalysis
We determined the X‐ray crystallographic structure of a unique hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensi s, and elucidated the reaction mechanism. We revealed that it belongs to the lipocalins, a family of proteins active in the transport small hydrophobic molecules. It is one of a few lipocalins with enzyme activities. This addition expands the evolutionary relationship of the enzyme to a new family of proteins.