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Osmostress‐induced gene expression – a model to understand how stress‐activated protein kinases ( SAPK s) regulate transcription
Author(s) -
Nadal Eulàlia,
Posas Francesc
Publication year - 2015
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13323
Subject(s) - adaptation (eye) , biology , biogenesis , microbiology and biotechnology , gene expression , gene , yeast , regulation of gene expression , transcription factor , cell , environmental stress , kinase , signal transduction , transcription (linguistics) , genetics , ecology , neuroscience , linguistics , philosophy
Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are associated with cell exposure to environmental changes, and several aspects of mRNA biogenesis appear to be targeted by signaling pathways upon stress. Exhaustive reviews have been written regarding adaptation to stress and regulation of gene expression. In this review, using osmostress in yeast as a prototypical case study, we highlight those aspects of regulation of gene induction that are general to various environmental stresses as well as mechanistic aspects that are potentially conserved from yeast to mammals.

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