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The development of antimelanogenic agents is important for the prevention of serious aesthetic problems such as melasma, freckles, age spots and chloasma. The aim of this study was to investigate the antimelanogenic effect of sesamol, an active lignan isolated from  Sesamum indicum , in melan‐a cells. Sesamol strongly inhibited melanin biosynthesis and the activity of intracellular tyrosinase by decreasing cyclic adenosine monophosphate ( cAMP ) accumulation. Sesamol significantly decreased the expression of melanogenesis‐related genes, such as tyrosinase, tyrosinase‐related protein‐1,2 ( TRP ‐1,2), microphthalmia‐associated transcription factor ( MITF ) and melanocortin 1 receptor ( MC 1R). In addition, sesamol also induces phosphorylation of p38 mitogen‐activated protein kinase (p38  MAPK ) and c‐Jun N‐terminal kinase ( JNK ). Moreover, sesamol dose‐dependently decreased zebrafish pigment formation, tyrosinase activity and expression of melanogenesis‐related genes. These findings indicate that sesamol inhibited melanin biosynthesis by down‐regulating tyrosinase activity and melanin production via regulation of gene expression of melanogenesis‐related proteins through modulation of  MITF  activity, which promoted phosphorylation of p38 and  JNK  in melan‐a cells. Together, these results suggest that sesamol strongly inhibits melanin biosynthesis, and therefore, sesamol represents a new skin‐whitening agent for use in cosmetics.

experimental dermatology

Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of  MITF  via the intracellular  cAMP  and p38/ JNK  signalling pathways