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Correlation of FDG ‐ PET hypometabolism and SEEG epileptogenicity mapping in patients with drug‐resistant focal epilepsy
Author(s) -
Lamarche Florence,
Job AnneSophie,
Deman Pierre,
Bhattacharjee Manik,
Hoffmann Dominique,
GallazziniCrépin Céline,
Bouvard Sandrine,
Minotti Lorella,
Kahane Philippe,
David Olivier
Publication year - 2016
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.13592
Subject(s) - stereoelectroencephalography , epilepsy , medicine , correlation , pathology , neuroscience , psychology , epilepsy surgery , geometry , mathematics
Summary Objective Interictal [18F]fluorodeoxyglucose–positron emission tomography ( FDG ‐ PET ) is used in the presurgical evaluation of patients with drug‐resistant focal epilepsy. We aimed at clarifying its relationships with ictal high‐frequency oscillations ( iHFO s) shown to be a relevant marker of the seizure‐onset zone. Methods We studied the correlation between FDG ‐ PET and epileptogenicity maps in an unselected series of 37 successive patients having been explored with stereo‐electroencephalography (SEEG). Results At the group level, we found a significant correlation between iHFO s and FDG ‐ PET interictal hypometabolism only in cases of temporal lobe epilepsy. This correlation was found with HFO s, and the same comparison between FDG ‐ PET and ictal SEEG power of lower frequencies during the same epochs did not show the same significance. Significance This finding suggests that interictal FDG ‐ PET and ictal HFO s may share common underlying pathophysiologic mechanisms of ictogenesis in temporal lobe epilepsy, and combining both features may help to identify the seizure‐onset zone.