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Background and purpose  Muscle‐strengthening, stretching or proprioceptive treatments may slow symptom progression in Charcot—Marie–Tooth ( CMT ) neuropathy. The aim of the study was to evaluate safety and efficacy of treadmill training in  CMT 1A.    Methods  We planned a multicenter, prospective, randomized, single‐blind, controlled study. We recruited 53 outpatients affected by  CMT 1A and randomized them into two treatment groups: one underwent stretching and proprioceptive exercise, whereas the other was additionally treated with treadmill training (Tre SPE ). Primary outcome measures ( OMs ) were the walking evaluations and secondary  OM  was the balance assessment. All participants were assessed at baseline and after 3 and 6 months of treatment.    Results  Most patients showed an improvement in at least one  OM  after 3 months [42/47 (89.4%)] and 6 months [38/40 (95%)] of treatment. No adverse events were reported in either group.    Conclusions  The most important finding was that both stretching and proprioceptive exercise and treadmill training had an objective benefit on patients affected by  CMT  disease, without causing overwork weakness. We had a low rate of drop out and did not find deterioration in motor performance. Our results also confirm that applying evidence‐based medicine methods to rehabilitative research is the correct way to test the efficacy of a treatment.

european journal of neurology

Treadmill training in patients affected by Charcot–Marie–Tooth neuropathy: results of a multicenter, prospective, randomized, single‐blind, controlled study