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Asymmetric left–right hippocampal glutamatergic modulation of cognitive control in ApoE‐isoform subjects is unrelated to neuroinflammation
Author(s) -
Zhang Hui,
Chiu Pui Wai,
Ip Isaac,
Liu Tianyin,
Wong Gloria Hoi Yan,
Song YouQiang,
Wong Savio Wai Ho,
Herrup Karl,
Mak Henry Ka Fung
Publication year - 2021
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.15399
Subject(s) - glutamatergic , neuroscience , hippocampal formation , neuroinflammation , functional magnetic resonance imaging , psychology , medicine , glutamate receptor , receptor , inflammation
Abstract The glutamatergic cycle is essential in modulating memory processing by the hippocampal circuitry. Our combined proton magnetic resonance spectroscopy ( 1 H‐MRS) and task‐based functional magnetic resonance imaging (fMRI) study (using face‐name paired‐associates encoding and retrieval task) of a cognitively normal cohort of 67 healthy adults (18 ApoE4 carriers and 49 non‐ApoE4 carriers) found altered patterns of relationships between glutamatergic‐modulated synaptic signalling and neuronal activity or functional hyperaemia in the ApoE4 isoforms. Our study highlighted the asymmetric left–right hippocampal glutamatergic system in modulating neuronal activities in ApoE4 carriers versus non‐carriers. Such brain differentiation might be developmental cognitive advantages or compensatory due to impaired synaptic integrity and plasticity in ApoE4 carriers. As there was no difference in myoinositol levels measured by MRS between the ApoE4 and non‐ApoE4 subgroups, the mechanism is unlikely to be a response to neuroinflammation.