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Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force
Author(s) -
Parmar Malin,
Torper Olof,
DrouinOuellet Janelle
Publication year - 2019
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.14109
Subject(s) - parallels , great rift , disease , psychoanalysis , parkinson's disease , neuroscience , psychology , medicine , pathology , mechanical engineering , physics , astronomy , engineering
This review describes the history, development, and evolution of cell‐based replacement therapy for Parkinson's disease ( PD ), from the first pioneering trials with fetal ventral midbrain progenitors to future trials using stem cells as well as reprogrammed cells. In the spirit of Tom Isaacs, the review takes parallels to the storyline of Star Wars, including the temptations from the dark side and the continuous fight for the light side of the Force. It is subdivided into headings based on the original movies, spanning from A New Hope to the Last Jedi.