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The mouse olfactory system employs ~1100 G‐protein‐coupled odorant receptors ( OR s). Each mature olfactory sensory neuron ( OSN ) is thought to express just one  OR  gene, and the expressed  OR  determines the odorant response properties of the  OSN . The broadest odorant response profile thus far demonstrated in native mouse  OSN s is for  OSN s that express the  OR  gene   SR 1  (also known as  Olfr124  and   MOR 256‐3 ). Here we showed that the odorant responsiveness of native mouse  OSN s expressing the  OR  gene   MOR 256‐17  (also known as  Olfr15  and   OR 3 ) is even broader than that of  OSN s expressing   SR 1 . We investigated the electrophysiological properties of green fluorescent protein ( GFP )+  OSN s in a  MOR 256‐17‐ IRES ‐tau GFP  gene‐targeted mouse strain, in parallel with  GFP +  OSN s in the  SR 1‐ IRES ‐tau GFP  gene‐targeted mouse strain that we previously reported. Of 35 single chemical compounds belonging to distinct structural classes,  MOR 256‐17+  OSN s responded to 31 chemicals, compared with 10 for  SR 1+  OSN s. The 10 compounds that activated  SR 1+  OSN s also activated  MOR 256‐17+  OSN s. Interestingly,  MOR 256‐17+  OSN s were activated by three amines (cyclohexylamine, isopenthylamine, and phenylethylamine) that are typically viewed as ligands for chemosensory neurons in the main olfactory epithelium that express trace amine‐associated receptor genes, a family of 15 genes encoding G‐protein‐coupled receptors unrelated in sequence to  OR s. We did not observe differences in membrane properties, indicating that the differences in odorant response profiles between the two  OSN  populations were due to the expressed  OR .  MOR 256‐17+  OSN s appear to be at one extreme of odorant responsiveness among populations of  OSN s expressing distinct  OR  genes in the mouse.

european journal of neuroscience

The extremely broad odorant response profile of mouse olfactory sensory neurons expressing the odorant receptor MOR256‐17 includes trace amine‐associated receptor ligands