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Prognostic impact of abdominal lymph node involvement in diffuse large B‐cell lymphoma
Author(s) -
Abdulla Maysaa,
Guglielmo Priscilla,
Hollander Peter,
Åström Gunnar,
Ahlström Håkan,
Enblad Gunilla,
Amini RoseMarie
Publication year - 2020
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13361
Subject(s) - medicine , abdomen , lymphoma , lymph node , diffuse large b cell lymphoma , radiology , stage (stratigraphy) , biopsy , lymph , nodal , pathology , gastroenterology , paleontology , biology
Objective The prognostic value of site of nodal involvement in diffuse large B‐cell lymphomas (DLBCL) is mainly unknown. We aimed to determine the prognostic significance of nodal abdominal involvement in relation to tumour cell markers and clinical characteristics of 249 DLBCL patients in a retrospective single‐centre study. Methods Contrast‐enhanced computed tomography (CT) of the abdomen and thorax revealed pathologically enlarged abdominal lymph nodes in 156 patients, while in 93 patients there were no pathologically enlarged lymph nodes in the abdomen. In 81 cases, the diagnosis of DLBCL was verified by histopathological biopsy obtained from abdominal lymph node. Results Patients with abdominal nodal disease had inferior lymphoma‐specific survival ( P = .04) and presented with higher age‐adjusted IPI ( P < .001), lactate dehydrogenase ( P < .001) and more often advanced stage ( P < .001), bulky disease ( P < .001), B symptoms ( P < .001), and double expression of MYC and BCL2 ( P = .02) compared to patients without nodal abdominal involvement, but less often extranodal involvement ( P < .02). The worst outcome was observed in those where the abdominal nodal involvement was verified by histopathological biopsy. Conclusion Diffuse large B‐cell lymphomas patients with abdominal nodal disease had inferior outcome and more aggressive behaviour, reflected both in clinical and biological characteristics.