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Secondary primary cancer in patients with head and neck carcinoma: the differences among hypopharyngeal, laryngeal, and other sites of head and neck cancer
Author(s) -
Liu WS.,
Chang YJ.,
Lin CL.,
Liang JA.,
Sung FC.,
Hwang IM.,
Kao CH.
Publication year - 2014
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12084
Subject(s) - medicine , cohort , head and neck cancer , hypopharyngeal cancer , retrospective cohort study , hazard ratio , incidence (geometry) , cancer , cohort study , cancer registry , proportional hazards model , oncology , surgery , confidence interval , physics , optics
This paper presents a population‐based retrospective cohort study to identify the differences in secondary primary cancer ( SPC ) among hypopharyngeal, laryngeal, and other sites of head and neck cancer ( HNC ). Data were collected from the T aiwan N ational H ealth I nsurance R esearch D atabase ( NHIRD ) for the period 1979–2010. The study cohort comprised 5914 newly diagnosed hypopharyngeal and laryngeal patients from the registry of the C atastrophic I llness P atients D atabase ( CIPD ). The comparison cohort comprised 5914 patients with other sites of HNC . We used a multivariate C ox proportional‐hazards regression model to assess the risk of developing SPC . The incidence of SPC in the study cohort was 68% higher compared with the comparison cohort (23.9 vs. 14.2 per 1000 person‐years, Incident Rate Ratio = 1.68). The study cohort had a higher adjusted hazard ratio ( HR ) in oesophageal cancer ( HR = 3.47) and lung cancer ( HR = 1.89). The difference in SPC incidence between the study and comparison cohort was significant.