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Cerebral effects of glucagon‐like peptide‐1 receptor blockade before and after Roux‐en‐Y gastric bypass surgery in obese women: A proof‐of‐concept resting‐state functional MRI study
Author(s) -
Duinkerken Eelco,
Bernardes Gabriel,
Bloemendaal Liselotte,
Veltman Dick J.,
Barkhof Frederik,
Mograbi Daniel C.,
Gerdes Victor E. A.,
Deacon Carolyn F.,
Holst Jens J.,
Drent Madeleine L.,
Diamant Michaela,
Kulve Jennifer,
Ijzerman Richard G.
Publication year - 2021
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.14233
Subject(s) - default mode network , gastric bypass surgery , blockade , insula , orbitofrontal cortex , medicine , peptide yy , resting state fmri , appetite , roux en y anastomosis , anterior cingulate cortex , endocrinology , weight loss , psychology , neuroscience , receptor , functional magnetic resonance imaging , obesity , gastric bypass , prefrontal cortex , neuropeptide y receptor , neuropeptide , cognition
Aim To assess the effects of Roux‐en‐Y gastric bypass surgery (RYGB)‐related changes in glucagon‐like peptide‐1 (GLP‐1) on cerebral resting‐state functioning in obese women. Materials and Methods In nine obese females aged 40‐54 years in the fasted state, we studied the effects of RYGB and GLP‐1 on five a priori selected networks implicated in food‐ and reward‐related processes as well as environment monitoring (default mode, right frontoparietal, basal ganglia, insula/anterior cingulate and anterior cingulate/orbitofrontal networks). Results Before surgery, GLP‐1 receptor blockade (using exendin9‐39) was associated with increased right caudate nucleus (basal ganglia network) and decreased right middle frontal (right frontoparietal network) connectivity compared with placebo. RYGB resulted in decreased right orbitofrontal (insula/anterior cingulate network) connectivity. In the default mode network, after surgery, GLP‐1 receptor blockade had a larger effect on connectivity in this region than GLP‐1 receptor blockade before RYGB (all P FWE < .05). Results remained similar after correction for changes in body weight. Default mode and right frontoparietal network connectivity changes were related to changes in body mass index and food scores after RYGB. Conclusions These findings suggest GLP‐1 involvement in resting‐state networks related to food and reward processes and monitoring of the internal and external environment, pointing to a potential role for GLP‐1–induced changes in resting‐state connectivity in RYGB‐mediated weight loss and appetite control.