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The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men
Author(s) -
Nahon Kimberly J.,
Janssen Laura G. M.,
Sardjoe Mishre Aashley S. D.,
Bilsen Manu P.,
Eijk Jari A.,
Botani Kani,
Overduin Lisanne A.,
Ruiz Jonatan R.,
Burakiewicz Jedrzej,
Dzyubachyk Oleh,
Webb Andrew G.,
Kan Hermien E.,
Berbée Jimmy F. P.,
Klinken JanBert,
Dijk Ko Willems,
Weeghel Michel,
Vaz Frédéric M.,
Coskun Tamer,
Jazet Ingrid M.,
Kooijman Sander,
MartinezTellez Borja,
Boon Mariëtte R.,
Rensen Patrick C. N.
Publication year - 2020
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.14120
Subject(s) - mirabegron , brown adipose tissue , endocrinology , adipose tissue , medicine , placebo , lipid profile , lipid oxidation , chemistry , cholesterol , biochemistry , pathology , antioxidant , alternative medicine , overactive bladder
Aim To compare the effects of cold exposure and the β3‐adrenergic receptor agonist mirabegron on plasma lipids, energy expenditure and brown adipose tissue (BAT) activity in South Asians versus Europids. Materials and Methods Ten lean Dutch South Asian (aged 18‐30 years; body mass index [BMI] 18‐25 kg/m 2 ) and 10 age‐ and BMI‐matched Europid men participated in a randomized, double‐blinded, cross‐over study consisting of three interventions: short‐term (~ 2 hours) cold exposure, mirabegron (200 mg one dose p.o.) and placebo. Before and after each intervention, we performed lipidomic analysis in serum, assessed resting energy expenditure (REE) and skin temperature, and measured BAT fat fraction by magnetic resonance imaging. Results In both ethnicities, cold exposure increased the levels of several serum lipid species, whereas mirabegron only increased free fatty acids. Cold exposure increased lipid oxidation in both ethnicities, while mirabegron increased lipid oxidation in Europids only. Cold exposure and mirabegron enhanced supraclavicular skin temperature in both ethnicities. Cold exposure decreased BAT fat fraction in both ethnicities. After the combination of data from both ethnicities, mirabegron decreased BAT fat fraction compared with placebo. Conclusions In South Asians and Europids, cold exposure and mirabegron induced beneficial metabolic effects. When combining both ethnicities, cold exposure and mirabegron increased REE and lipid oxidation, coinciding with a higher supraclavicular skin temperature and lower BAT fat fraction.