Premium
Trial design and baseline data for LIRA‐PRIME: A randomized trial investigating the efficacy of liraglutide in controlling glycaemia in type 2 diabetes in a primary care setting
Author(s) -
Unger Jeff,
Allison Dale C.,
Carlton Melissa,
Lakkole Kavitha,
Lowe Derek,
Murphy Gerri,
Panda Jayant K.,
Sargin Mehmet,
Kaltoft Margit,
Treppendahl Marianne B.,
Zoghbi Marouan
Publication year - 2019
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13682
Subject(s) - medicine , liraglutide , clinical endpoint , randomized controlled trial , type 2 diabetes , metformin , overweight , diabetes mellitus , glycated hemoglobin , pediatrics , insulin , obesity , endocrinology
Aims Using a pragmatic approach, the LIRA‐PRIME trial aims to address a knowledge gap by comparing efficacy in controlling glycaemia with glucagon‐like peptide‐1 analog liraglutide vs oral antidiabetic drugs (OADs) in patients with type 2 diabetes (T2D) uncontrolled with metformin monotherapy in primary care practice. We report the study design and patient baseline characteristics. Materials and methods This 104‐week, two‐arm, open‐label, active‐controlled trial is active in 219 primary care practices across nine countries. At screening, eligible patients with T2D were at least 18 years of age, had been using a stable daily dose of metformin ≥1500 mg or the maximum tolerated dose for ≥60 days, and had a glycated haemoglobin (HbA1c) of 7.5% to 9.0%, measured ≤90 days before screening. Patients were randomized (1:1) to liraglutide or OAD, both in addition to pre‐trial metformin. Individual OADs were chosen by the treating physician based on local guidelines. The primary endpoint is time to inadequate glycaemic control, defined as HbA1c above 7.0% at two scheduled consecutive visits after the first 26 weeks of treatment. Results The trial randomized 1997 patients with a mean (standard deviation) age of 56.9 (10.8) years, T2D duration of 7.2 (5.9) years (range, <1‐47 years), and HbA1c of 8.2%. One‐fifth of patients had a history of diabetes complications, and most were overweight (24.8%) or had obesity (65.3%). Conclusions This pragmatically designed, large‐scale, multinational, randomized clinical trial will help guide treatment decisions for patients with T2D who are inadequately controlled with metformin monotherapy and treated in primary care.