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Similar risk of exercise‐related hypoglycaemia for insulin degludec to that for insulin glargine in patients with type 1 diabetes: a randomized cross‐over trial
Author(s) -
Heise T.,
Bain S. C.,
Bracken R. M.,
Zijlstra E.,
Nosek L.,
StenderPetersen K.,
Rabøl R.,
Rowe E.,
Haahr H. L.
Publication year - 2016
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12588
Subject(s) - medicine , insulin glargine , insulin degludec , insulin , crossover study , diabetes mellitus , hypoglycemia , endocrinology , randomized controlled trial , confidence interval , type 2 diabetes , type 1 diabetes , placebo , alternative medicine , pathology
We compared changes in blood glucose ( BG ) and risk of hypoglycaemia during and after exercise in 40 patients with type 1 diabetes ( T1D ) treated with insulin degludec ( IDeg ) or insulin glargine ( IGlar ) in a randomized, open‐label, two‐period, crossover trial. After individual titration and a steady‐state period, patients performed 30 min of moderate‐intensity cycle ergometer exercise (65% peak rate of oxygen uptake). BG , counter‐regulatory hormones and hypoglycaemic episodes were measured frequently during and for 24 h after exercise. BG changes during exercise were similar with IDeg and IGlar [estimated treatment difference ( ETD ) for maximum BG decrease: 0.14 mmol/l; 95% confidence interval ( CI ) −0.15, 0.42; p = 0.34], as was mean BG ( ETD −0.16 mmol/l; 95% CI −0.36, 0.05; p = 0.13). No hypoglycaemic episodes occurred during exercise. Post‐exercise mean BG , counter‐regulatory hormone response and number of hypoglycaemic episodes in 24 h after starting exercise were similar with IDeg (18 events in 13 patients) and IGlar (23 events in 15 patients). This clinical trial showed that, in patients with T1D treated with a basal‐bolus regimen, the risk of hypoglycaemia induced by moderate‐intensity exercise was low with IDeg and similar to that with IGlar .