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Aim  To compare using propensity score analysis the outcome of beginning insulin therapy with basal, premix, mealtime + basal or mealtime insulin on the basis of data from 3031 people from the observational  CREDIT  (Cardiovascular Risk Evaluation in People with Type 2 Diabetes on Insulin Therapy) study. This approach overcomes likely confounding in baseline and unknown characteristics common to observational studies.    Methods  Efficacy and safety outcomes were collected at baseline and at 1 year in previously insulin‐naïve people. Propensity score matched groups using all available baseline data were defined to compare outcomes by pairs of insulin regimens.    Results  From 2659 people with available data, propensity score matches were achieved for 686 people starting premix or basal insulin, 542 starting basal + mealtime or premix insulin and 400 starting basal or basal + mealtime.  HbA1c  reduction did not differ between the three pairs of insulin regimens. However, the relative risk of overall and nocturnal hypoglycaemia was lower (p = 0.010 to p < 0.001) with basal or basal + mealtime compared with premix insulin, and for nocturnal (p = 0.021) but not overall hypoglycaemia for basal compared to basal + mealtime insulin. Body weight increase was less for basal versus premix insulin [–1.3 (95%  CI  –2.1, –0.6) kg, p < 0.001] or versus basal + mealtime insulin [–1.4 (–2.5, –0.3) kg, p = 0.016], but did not differ between basal + mealtime and premix. Smaller groups matching mealtime insulin had some residual mismatching of  HbA1c .    Conclusion  Comparing insulin regimens between individuals matched by propensity scores indicated differences in hypoglycaemia and body weight change, despite similar  HbA1c  reductions. Our findings are consistent with those from randomized controlled trials.

A propensity score matched comparison of different insulin regimens 1 year after beginning insulin in people with type 2 diabetes