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Aims  To examine the association between 24 literature‐based single nucleotide polymorphisms and diabetic kidney disease in Chinese people with type 2 diabetes.    Methods and results  Twenty‐four candidate diabetic kidney disease‐susceptible single nucleotide polymorphisms were genotyped in 208 participants with type 2 diabetes and diabetic kidney disease and 200 participants with type 2 diabetes without diabetic kidney disease (case and control groups, respectively), together with 206 healthy participants using MassARRAY. Rs11643718 in the  SLC12A3  gene was associated with diabetic kidney disease in the recessive model after adjusting for confounding factors, such as age and gender (adjusted odds ratio 2.056, 95% CI 1.120–3.776;  P  = 0.020). Meta‐analyses further confirmed the association ( P  = 0.002). In addition, participants with the  GG  genotype had worse renal function and more albuminuria than those with the  AA + AG  genotype ( P  < 0.05). Renal section immunohistochemistry was conducted in participants with type 2 diabetes, diabetic kidney disease and  AA+AG  or  GG  genotypes and in participants with glomerular minor lesions. Together with data from the Nephroseq database, it was shown that the abundance of  SLC12A3  was reduced in patients with the  GG  genotype, while elevated expression of  SLC12A3  was associated with better renal function. In addition, rs10951509 and rs1345365 in  ELMO1 , which were determined to be in high linkage disequilibrium by SHEsis software, were also associated with diabetic kidney disease (adjusted  P  = 0.010 and 0.015, respectively).    Conclusions  The  G  allele and  GG  genotype of  SLC12A3  rs11643718 are associated with the development of diabetic kidney disease in a Chinese population with type 2 diabetes.

diabetic medicine

The single nucleotide polymorphism rs11643718 in  SLC12A3  is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes