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Neurodevelopmental profiles of children with unilateral cerebral palsy associated with middle cerebral artery and periventricular venous infarctions
Author(s) -
Fehlings Darcy,
Krishnan Pradeep,
Ragguett ReneeMarie,
deVeber Gabrielle,
Gorter Jan Willem,
Hunt Carolyn,
Kim Marie,
Mesterman Ronit,
M Anna
Publication year - 2021
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.14818
Subject(s) - interquartile range , medicine , gross motor function classification system , middle cerebral artery , mann–whitney u test , cerebral palsy , confidence interval , odds ratio , stroke (engine) , pediatrics , physical therapy , mechanical engineering , ischemia , engineering
Aim To compare the neurodevelopment of children with unilateral cerebral palsy (CP) with middle cerebral artery (MCA) and periventricular venous infarctions (PVIs). Method In this cross‐sectional study, children with unilateral CP completed a neurological exam, unimanual Quality of Upper Extremity Skills Test, hand usage questionnaires, and IQ test. Neuroimaging was obtained from health records. Results Two hundred and forty‐five participants with unilateral CP had neuroimaging (151 [61.9%] male, ages 2–18y, median=7y 6mo, interquartile range [IQR]=6y 7mo, with 93.6% in Gross Motor Function Classification System level I/II and 78.8% in Manual Ability Classification System level I/II). Ninety‐seven (39.6%) had MCA injuries and 106 (43.3%) had periventricular white matter injuries, of which 48 (45.3%) were PVIs. Median Quality of Upper Extremity Skills Test for the MCA group was 49.2 (IQR=55.8), PVI 79.9 (IQR=23.6) (Mann–Whitney U =988.50, p <0.001). Bimanual hand usage (Children's Hand‐use Experience Questionnaire) (Mann–Whitney U =425, p <0.001) and light touch (odds ratio=9.12, 95% confidence interval 1.28–400.76, Fisher's exact test p =0.017) were lower in the MCA compared to the PVI group. Full‐scale IQ median centile score for the MCA group was 18.0 (IQR=35.5) and 50.0 (IQR=30.0) for the PVI group (Mann–Whitney U =382, p <0.001). Interpretation Children with unilateral CP and MCA injuries demonstrated lower hand function and usage, decreased light touch, and lower IQs compared to the PVI group. This study aids in defining rehabilitation needs informed by brain injury patterns.