Premium
Asymmetric cell division from a cell to cells: Shape, length, and location of polarity domain
Author(s) -
SeirinLee Sungrim
Publication year - 2020
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12652
Subject(s) - polarity (international relations) , asymmetric cell division , cell polarity , cell division , division (mathematics) , domain (mathematical analysis) , mechanism (biology) , perspective (graphical) , cell , microbiology and biotechnology , biology , computer science , physics , mathematics , genetics , artificial intelligence , mathematical analysis , arithmetic , quantum mechanics
Asymmetric cell division is one of the most elegant biological systems by which cells create daughter cells with different functions and increase cell diversity. In particular, PAR polarity in the cell membrane plays a critical role in regulating the whole process of asymmetric cell division. Numerous studies have been conducted to determine the underlying mechanism of PAR polarity formation using both experimental and theoretical approaches in the last 10 years. However, they have mostly focused on answering the fundamental question of how this exclusive polarity is established but the precise dynamics of polarity domain have been little notified. In this review, I focused on studies on the shape, length, and location of PAR polarity from a theoretical perspective that may be important for an integrated understanding of the entire process of asymmetric cell division.