English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Coproporphyrin‐I (CP‐I) in plasma is a sensitive and specific endogenous probe for phenotyping organic anion transporting polypeptides 1B (OATP1B, encoded by  SLCO1B ). A few small‐scale studies suggested that plasma CP‐I concentration is affected by OATP1B1 polymorphism, but detailed studies are lacking. In this large‐scale study, we measured plasma CP‐I concentrations in 391 subjects from the Japanese general population, and evaluated the relationship between plasma CP‐I concentrations and  OATP1B1  polymorphisms to further assess the utility of plasma CP‐I concentrations as an endogenous OATP1B probe. Plasma CP‐I concentrations were 0.45 ± 0.12, 0.47 ± 0.16, 0.47 ± 0.20, 0.50 ± 0.15, 0.54 ± 0.14, and 0.74 ± 0.31 ng/mL in participants with  OATP1B1*1b/*1b  ( n  = 103),  *1a/*1b  ( n  = 122),  *1a/*1a  ( n  = 40),  *1b/*15  ( n  = 74),  *1a/*15  ( n  = 41), and  *15/*15  ( n  = 11), respectively, showing an ascending rank order with significant difference ( P  < 0.0001).  Post hoc  analysis revealed significant increases in plasma CP‐I concentration in  OATP1B1*1b/*15  ( P  = 0.036),  *1a/*15  ( P  = 0.0005), and  *15/*15  ( P  = 0.0003) groups compared with the  OATP1B1*1b/*1b  group. There was no significant difference among  OATP1B  genotypes in plasma concentration of 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid, a uremic toxin reported to decrease OATP1B activity  in vivo . These findings confirm the utility of plasma CP‐I concentrations as an endogenous biomarker for phenotyping of OATP1B activity. Plasma CP‐I concentration is potentially useful for the study of drug‐drug interactions via OATP1B or individual dose adjustment of OATP1B substrates.

Substantially Increased Plasma Coproporphyrin‐I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population