Open Accesssi RNA Targeting and Treatment of Gastrointestinal Diseases
Author(s) -
Chevalier Rachel
Publication year - 2019
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12668
Subject(s) - small interfering rna , rna interference , rna , gastrointestinal tract , medicine , disease , bioinformatics , cancer research , biology , gene , pathology , biochemistry
RNA interference via small interfering RNA (si RNA ) offers opportunities to precisely target genes that contribute to gastrointestinal ( GI ) pathologies, such as inflammatory bowel disease, celiac, and esophageal scarring. Delivering the si RNA to the GI tract proves challenging as the harsh environment of the intestines degrades the si RNA before it can reach its target or blocks its entry into its site of action in the cytoplasm. Additionally, the GI tract is large and disease is often localized to a specific site. This review discusses polymer and lipid‐based delivery systems for protection and targeting of si RNA therapies to the GI tract to treat local disease.