Open AccessThe ACCO u NT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans
Author(s) -
Friedman Paula N.,
Shaazuddin Mohammed,
Gong Li,
Grossman Robert L.,
Harralson Arthur F.,
Klein Teri E.,
Lee Norman H.,
Miller Doriane C.,
Nutescu Edith A.,
O'Brien Travis J.,
O'Donnell Peter H.,
O'Leary Kevin J.,
Tuck Matthew,
Meltzer David O.,
Perera Minoli A.
Publication year - 2019
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12608
Subject(s) - pharmacogenomics , precision medicine , african american , pharmacogenetics , translation (biology) , population , medicine , computational biology , gerontology , family medicine , biology , bioinformatics , genetics , genotype , gene , anthropology , environmental health , sociology , messenger rna
The majority of pharmacogenomic (PGx) studies have been conducted on European ancestry populations, thereby excluding minority populations and impeding the discovery and translation of African American–specific genetic variation into precision medicine. Without accounting for variants found in African Americans, clinical recommendations based solely on genetic biomarkers found in European populations could result in misclassification of drug response in African American patients. To address these challenges, we formed the Transdisciplinary Collaborative Center ( TCC ), African American Cardiovascular Pharmacogenetic Consortium ( ACCO u NT ), to discover novel genetic variants in African Americans related to clinically actionable cardiovascular phenotypes and to incorporate African American–specific sequence variations into clinical recommendations at the point of care. The TCC consists of two research projects focused on discovery and translation of genetic findings and four cores that support the projects. In addition, the largest repository of PGx information on African Americans is being established as well as lasting infrastructure that can be utilized to spur continued research in this understudied population.