Open AccessClinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years
Author(s) -
Borobia Alberto M.,
Dapia Irene,
Tong Hoi Y.,
Arias Pedro,
Muñoz Mario,
Tenorio Jair,
Hernández Rafael,
García García Irene,
Gordo Gema,
Ramírez Elena,
Frías Jesús,
Lapunzina Pablo,
Carcas Antonio J.
Publication year - 2018
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12526
Subject(s) - pharmacogenetics , medicine , genotyping , single nucleotide polymorphism , genetic testing , medical physics , genotype , genetics , biology , gene
In 2014, we established a pharmacogenetics unit with the intention of facilitating the integration of pharmacogenetic testing into clinical practice. This unit was centered around two main ideas: i) individualization of clinical recommendations, and ii) preemptive genotyping in risk populations. Our unit is based on the design and validation of a single nucleotide polymorphism (SNP) microarray, which has allowed testing of 180 SNPs associated with drug response (PharmArray), and clinical consultation regarding the results. Herein, we report our experience in integrating pharmacogenetic testing into our hospital and we present the results of the 2,539 pharmacogenetic consultation requests received over the past 3 years in our unit. The results demonstrate the feasibility of implementing pharmacogenetic testing in clinical practice within a national health system.