Open AccessGenome‐wide and Phenome‐wide Approaches to Understand Variable Drug Actions in Electronic Health Records
Author(s) -
Robinson Jamie R.,
Denny Joshua C.,
Roden Dan M.,
Driest Sara L.
Publication year - 2018
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12522
Subject(s) - library science , medicine , health informatics , public health , computer science , nursing
Genome‐wide association studies (GWAS) and phenome‐wide association studies (PheWAS) have provided powerful methods for investigating the impact of genetic variation on individual drug response and have added extensive knowledge to the understanding of drug targets and effects. We highlight here recent advances in drug development, repurposing, and personalization accelerated by applying GWAS and PheWAS to longitudinal health data information, along with limitations of these methods.