z-logo
open-access-imgOpen Access
Using Physiologically Based Pharmacokinetic Modeling for Mechanistic Insight: Cases of Reverse Translation
Author(s) -
Edginton Andrea N.
Publication year - 2018
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12517
Subject(s) - translation (biology) , computational biology , computer science , chemistry , biology , biochemistry , messenger rna , gene
Observation of a clinical event can spur reflective thinking on its source. In pharmacology, adverse events are examples of observations for which deriving the cause is important. Moving from observation to mechanistic understanding requires the use of tools that explicitly delineate biological systems, mode of action, and disease pathophysiology. By expanding understanding of biological factors that influence these events, such tools may allow scientists to discover triggering processes, and once confirmed, a means of mitigation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here