Open AccessImportance of Drug Pharmacokinetics at the Site of Action
Author(s) -
Rizk ML,
Zou L,
Savic RM,
Dooley KE
Publication year - 2017
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12448
Subject(s) - pharmacokinetics , drug action , drug , site of action , pharmacology , microdialysis , medicine , pharmacodynamics , central nervous system
Pharmacological activity depends on adequate drug levels at the effect site, but access to these sites for pharmacokinetic sampling is often limited. Thus, we often rely on plasma concentrations as surrogates in efforts to understand exposure– response relationships. Recent advances in analytical and quantitative methodologies allow for more robust and often noninvasive assessments of drug pharmacokinetics at the site of action. This review highlights the advances made in estimating drug exposures in several compartments of interest.