English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Early acute antibody‐mediated rejection ( ABMR ) occurs more frequently in  ABO ‐incompatible ( ABO i) than in  ABO ‐compatible ( ABO c) kidney transplantation. This could lead to increased inflammation/scarring in the  ABO i grafts. Protocol biopsy data in  ABO i kidney recipients are scarce.    Methods  A single‐center retrospective matched cohort study was conducted. Eighty adult living donor ( LD ) renal transplant recipients without  HLA  donor‐specific antibodies ( DSA ) transplanted between 2009 and 2012 were included; 20  ABO i and 60  ABO c controls matched for donor age and transplantation year. Protocol biopsies at one yr were scored according to the Banff classification. Three sums of scores were constructed: tubulointerstitial inflammation ( t  +  i  = 0 vs. >0), microvascular inflammation ( g  + ptc = 0 vs. >0), scarring/hyalinosis (ci + ct + cv + ah ≤ 1 vs. >1. Scores and presence of subclinical rejection ( SCR ) at one yr were compared.    Results  Protocol biopsy findings at one yr in the  ABO i vs.  ABO c matched control group were not statistically different: ( t  +  i ) > 0, 30% vs. 20%; ( g  + ptc) > 0, 5% vs. 8%; (ci + ct + cv + ah) > 1, 85% vs. 60%, respectively. No transplant glomerulopathy occurred.  SCR  rate at one yr was 30% vs. 18%, subclinical  ABMR  5% vs. 7% (all with  de novo   HLA DSA ).    Conclusion  One‐year protocol biopsies of  ABO i and  ABO c  LD  recipients do not differ in chronic changes, inflammation, or  SCR s.

One‐year protocol biopsies from ABO ‐incompatible renal allografts compared with a matched cohort of ABO ‐compatible allografts