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One‐year protocol biopsies from ABO ‐incompatible renal allografts compared with a matched cohort of ABO ‐compatible allografts
Author(s) -
Dörje Christina,
Mjøen Geir,
Strøm Erik H.,
Holdaas Hallvard,
Jenssen Trond,
Øyen Ole,
Akalin Akkök Çigdem,
Cvancarova Milada,
Midtvedt Karsten,
Reisæter Anna Varberg
Publication year - 2015
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12515
Subject(s) - medicine , abo blood group system , subclinical infection , cohort , kidney transplantation , transplantation , gastroenterology , single center , biopsy , urology , retrospective cohort study , kidney , surgery
Early acute antibody‐mediated rejection ( ABMR ) occurs more frequently in ABO ‐incompatible ( ABO i) than in ABO ‐compatible ( ABO c) kidney transplantation. This could lead to increased inflammation/scarring in the ABO i grafts. Protocol biopsy data in ABO i kidney recipients are scarce. Methods A single‐center retrospective matched cohort study was conducted. Eighty adult living donor ( LD ) renal transplant recipients without HLA donor‐specific antibodies ( DSA ) transplanted between 2009 and 2012 were included; 20 ABO i and 60 ABO c controls matched for donor age and transplantation year. Protocol biopsies at one yr were scored according to the Banff classification. Three sums of scores were constructed: tubulointerstitial inflammation ( t + i = 0 vs. >0), microvascular inflammation ( g + ptc = 0 vs. >0), scarring/hyalinosis (ci + ct + cv + ah ≤ 1 vs. >1. Scores and presence of subclinical rejection ( SCR ) at one yr were compared. Results Protocol biopsy findings at one yr in the ABO i vs. ABO c matched control group were not statistically different: ( t + i ) > 0, 30% vs. 20%; ( g + ptc) > 0, 5% vs. 8%; (ci + ct + cv + ah) > 1, 85% vs. 60%, respectively. No transplant glomerulopathy occurred. SCR rate at one yr was 30% vs. 18%, subclinical ABMR 5% vs. 7% (all with de novo HLA DSA ). Conclusion One‐year protocol biopsies of ABO i and ABO c LD recipients do not differ in chronic changes, inflammation, or SCR s.