Open AccessInfluenza pneumonia among adolescents and adults: a concurrent comparison between influenza A ( H1N1 ) pdm09 and A ( H3N2 ) in the post‐pandemic period
Author(s) -
Yang Shu Qiao,
Qu Jiu Xin,
Wang Chen,
Yu Xiao Min,
Liu Ying Mei,
Cao Bin
Publication year - 2014
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12056
Subject(s) - medicine , pneumonia , pandemic , cohort , immunology , influenza a virus , cohort study , pneumococcal pneumonia , antibiotics , disease , virus , covid-19 , streptococcus pneumoniae , infectious disease (medical specialty) , microbiology and biotechnology , biology
Comparisons of the characteristics between the influenza A ( H1N1 ) pdm09 and common seasonal influenza are important for both clinical management and epidemiological studies. However, the differences between pandemic and seasonal influenza during the post‐pandemic period are poorly understood. Objectives The aim of our research was to investigate clinical and immune response differences between patients with influenza A ( H1N1 ) pdm09 pneumonia and seasonal influenza A ( H3N2 ) pneumonia in the post‐pandemic period. Methods During the first flu season in post‐pandemic period, patients from B eijing N etwork for A dult C ommunity‐ A cquired P neumonia present A ( H1N1 ) pdm09 or A ( H3N2 ) influenza were compared concurrently in the aspects of clinical characteristics and inflammatory profile in acute phase. Result Patients with A ( H1N1 ) pdm09 influenza pneumonia showed a close mean age to A ( H 3 N 2) pneumonia (51 ± 20 vs 53 ± 16, mean ± standard deviation, years) but tended to have more underlying diseases (32.8% vs 10%, P = 0.036). Although clinical characteristics were similar, no statistical difference were found in pneumonia severity index ( PSI ) score or intensive care unit admission rate or mortality, patients in A ( H1N1 ) pdm09 cohort present higher levels of aspartate aminotransferase, lactase dehydrogenase ( P = 0.006, 0.018, respectively) in blood and also longer duration of fever than A ( H3N2 ) cohort. Levels of interleukin ( IL )‐10 and IL ‐12 (p70) were higher in A ( H1N1 ) pdm09 cohort ( P = 0.031, 0.047, respectively). Conclusios During the first post‐pandemic flu season, patients with the A ( H1N1 ) pdm09 pneumonia showed similar clinical characteristics but slightly higher disease severity and stronger systemic inflammatory response than A ( H3N2 ) pneumonia.